I play a very conservative game in real estate investment so the chances that I lost are very low. This is what I do. I will only buy a house if I have enough cash to buy the house. Assuming the house $300K, I will have $100K down payment and take the $100K loan from bank and finally invest the difference (which is $100K) in other investment (e.g. stock, mutual funds and etc.) to make sure the investment that I invest are higher than the bank's interest. Therefore, the chances that I lost in real estate investment is very slim and plus the property appreciation, how can I lost the game?